Chelsea Handler and Andre Balazs have broken up yet again. The E! late night talk show host confirmed on her show, "Chelsea Lately," that she's once again single after dating Balazs on-and-off for two years. "Maybe I'll start dating a (woman)," Handler said during her interview with friend Mary McCormack.
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After nearly 13 years of marriage, Catherine Zeta-Jones and Michael Douglas 
After months of speculation, Liam Hemsworth's rep has confirmed that he and Miley Cyrus have ended their engagement. The couple first met on the set of 2010's "The Last Song," and have been together off-and-on since then. But to some, this development isn't as surprising as these splits:
Movie veteran Clint Eastwood and his wife of 17 years, Dina, have separated, according to 
George Clooney and Stacy Keibler were going strong -- and looking hot on the red carpet -- for two years, but in early July their photogenic romance came to an end.
"Vampire Diaries" stars Nina Dobrev and Ian Somerhalder had a relationship that sizzled on and off the small screen. But the two shocked fans when anonymous sources confirmed to 
Amidst reports 
Jane Seymour and James Keach 
Julianne Hough and Ryan Seacrest have decided to take a break after more than two years together, 
After 30 years of marriage, Danny DeVito, 67, and actress Rhea Perlman, 64, separated, DeVito's rep told CNN in 
Tom Cruise and Katie Holmes "amicably settled" their divorce in July 2012, just two weeks after Holmes filed for it, an attorney told CNN. Holmes and Cruise, who were married for five years, have one daughter together.
Former California Gov. Arnold Schwarzenegger and Maria Shriver separated in May 2011 after 25 years of marriage. The public has since learned of Schwarzenegger's affair with the family's housekeeper that resulted in the birth of his fifth child.
After almost seven years together, Kate Winslet and director Sam Mendes went their separate ways in March 2010. The couple said the split was mutual and that they would continue raising their children together.
Tom Cruise and Nicole Kidman collaborated on four films together, including the controversial "Eyes Wide Shut," during their 11-year marriage. The couple split in 2001.
Susan Sarandon and Tim Robbins split in 2009 after 23 years together. The pair, who met on the set of "Bull Durham," have two sons but never married.
Mia Farrow appeared in several of Woody Allen's films before the couple went their separate ways in 1992. The pair reportedly split after Farrow found out about Allen's sexual relationship with one of her adopted daughters, who Allen married in 1997.
Reese Witherspoon and Ryan Phillippe were married for seven years before calling it quits in 2006. The pair, who have two children together, finalized their divorce in 2008.
Brad Pitt and Jennifer Aniston's seven-year romance came to an end in 2005. Speculation over whether Angelina Jolie had anything to do with the breakup added a juicy angle to the split.
After years of rumors about drug abuse and separation, Whitney Houston and Bobby Brown publicly split in 2006 after 14 years of marriage.
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